β-Lapachone for cell activation
Catalog number
2262-5
Name
β-Lapachone for cell activation
Size
5 mg
Price
186.00 EUR
Supplier
Details
Description
Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM).
Peptide sequence
No
CAS number
4707-32-8
Molecular weight
242.27
Category
Biochemicals
Other name
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Molecular formula
C₁₅H₁₄O₃
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (100 mM) or EtOH (50 mM)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from light and mositure
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
