BIIB 021 for cell activation

A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC₅₀ values of 0.06, 0.31, and 0.14 µM, respectively.

No

848695-25-0

318.76

Biochemicals

6-Chloro-9-[(4-methoxy-3,5-dimethyl­-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024

C₁₄H₁₅ClN₆O

White to off-white solid

N/A

No

Yes

≥99% by HPLC

DMSO (~65 mg/ml) or EtOH (~3 mg/ml)

-20 ̊C

gel pack

36 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.