BIIB 021 for cell activation

Catalog number
2291-5
Name
BIIB 021 for cell activation
Size
5 mg
Price
142.00 EUR
Supplier

Details

Description
A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC₅₀ values of 0.06, 0.31, and 0.14 µM, respectively.
Peptide sequence
No
CAS number
848695-25-0
Molecular weight
318.76
Category
Biochemicals
Other name
6-Chloro-9-[(4-methoxy-3,5-dimethyl­-2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024
Molecular formula
C₁₄H₁₅ClN₆O
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99% by HPLC
Reconstitute instructions
DMSO (~65 mg/ml) or EtOH (~3 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.