Tipifarnib, Free base for cell activation

A potent, selective, nonpeptidomimetic inhibitor of farnesyl protein transferase (FPT), an enzyme involved in protein processing (farnesylation) for signal transduction. Displays significant antitumor effects in vivo.  Tipifarnib competitively inhibits the farnesylation of lamin B (IC₅₀ = 0.86 nM) and K-RasB (IC₅₀ = 7.9 nM) peptide substrates and inhibits the cell growth of ~75% of a panel of 53 human tumor cell lines tested.

No

192185-72-1

489.4

Biochemicals

(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; R-115777

C₂₇H₂₂Cl₂N₄O

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO (~ 15 mg/ml) or Ethanol (~ 10 mg/ml)

-20 ̊C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.