DUB Inhibitor, PR-619 for cell activation

Catalog number
2302-5
Name
DUB Inhibitor, PR-619 for cell activation
Size
5 mg
Price
132.00 EUR
Supplier

Details

Description
A cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Treatment of cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.
Peptide sequence
No
CAS number
2645-32-1
Molecular weight
223.28
Category
Biochemicals
Other name
2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine
Molecular formula
C₇H₅N₅S₂
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 5 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.