HDM Inhibitor, 2,4-PDCA for cell activation

A histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1 proteins with an IC₅₀ values of 4.3 µM for JARID1B and 4.1 µM for JARID1A. 2, 4-PDCA does not inhibit UTX even at 10 µM.

No

207671-42-9

185.13

Biochemicals

2,4-Pyridinecarboxylic acid, monohydrate

C₇H₅N₄ .H₂O

White solid

N/A

No

Yes

≥98% by titration

DMSO

-20 ̊C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.