Akt Inhibitor (10-NCP) for cell activation

Cell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.

N/A

925681-41-0

381.34

Biochemicals

10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride

C₂₀H₂₅ClN₂O∙HCl

White solid

N/A

No

Yes

≥98% by HPLC

DMSO (60 mg/ml) or H2O (1 mg/ml)

-20 ̊C

gel pack

36 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.