AS 604850 for cell activation
Catalog number
2339-5
Name
AS 604850 for cell activation
Size
5 mg
Price
273.00 EUR
Supplier
Details
Description
Cell-permeable. A selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS 604850 inhibits MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduces RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.
Peptide sequence
N/A
CAS number
648449-76-7
Molecular weight
285.22
Category
Biochemicals
Other name
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Molecular formula
C₁₁H₅F₂NO₄S
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (50 mg/ml) or Ethanol (5 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
