IWP-3 for cell activation
Catalog number
2349-1
Name
IWP-3 for cell activation
Size
1 mg
Price
115.00 EUR
Supplier
Details
Description
An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
Peptide sequence
N/A
CAS number
687561-60-0
Molecular weight
484.59
Category
Biochemicals
Other name
Inhibitor of Wnt Production-3; 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2- d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)-acetamide
Molecular formula
C₂₂H₁₇FN₄O₂S₃
Physical appearance
White to Off-white Solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (~2 mg/ml on warming)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
