L-NAME hydrochloride for cell activation

A pro-drug of L- NG-Nitro-L-arginine (L-NOARG). Hydrolysis of the methyl ester of L-NAME by cellular esterases converts it into a fully functional L-NOARG that exhibits some selectivity for inhibition of neuronal and endothelial NOS isoforms (Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively). L-NAME inhibits cGMP formation in endothelial cells with an IC₅₀ of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC₅₀ of 0.54 µM.

H-Arg(NO2)-OMeHCl

51298-62-5

269.69

Biochemicals

NG-Nitro-L-arginine methyl ester hydrochloride

C₇H₁₅N₅O₄.HCl

White solid

N/A

Yes

Yes

≥98%

DMSO (~ 5 mg/ml) or H2O (~50 mg/ml)

-20°C

gel pack

36 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.