EZCyp™ Active Human Cytochrome P450 3A4
Catalog number
7872-10
Name
EZCyp™ Active Human Cytochrome P450 3A4
Size
10 mg
Price
186.00 EUR
Supplier
Details
Target
EZCyp™ Active Human CYP3A4
Background
Cytochrome P450 3A4 (CYP3A4, EC 1.14.13.157) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are transformed to more hydrophilic products to facilitate excretion from the body. CYP3A4 is expressed in high levels in the liver and intestines, where it catalyzes oxidation of an extraordinarily wide variety of structurally distinct ligands. More than half of all small molecule drugs commonly used by humans are metabolized by CYP3A4. BioVision’s EZCypTM 3A4 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP 3A4 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
Concentration
N/A
Molecular weight
55 KDa
Synonym
Cytochrome P450 3A, Cytochrome P450 3A4, Cyt3A4, CYPIIIA, CYPIIIA4, CYP3A, CYP3A4, Microsomal cytochrome P450 3A4, active CYP3A, human cyp3a, human CYP3A4, recombinant human CYP3A4
Other name
Cytochrome P450 3A, Cytochrome P450 3A4, Cyt3A4, CYPIIIA, CYPIIIA4, CYP3A, CYP3A4, Microsomal cytochrome P450 3A4, active CYP3A, human cyp3a, human CYP3A4, recombinant human CYP3A4
NCBI gene number
1576
NCBI gene
CYP3A4
Gene source
Human
NCBI number
P08684
Recombinant
Yes
Source
Pichia pastoris
Purification
N/A
Tested applications
N/A, NA
Level of endotoxin
NA
Tested activity
BioVision K701, Metabolite HPLC
Biological activity
NA
Reesults
NA
Binding ability
NA
Unit
NA
Storage condition
-20°C
Shipping under
gel pack
Physical appearance
Dry powder
Physical properties
Lyophilized powder
How to reconstitute
100 mM Potassium Phosphate buffer, pH 7.7
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
