AT-101 for cell activation
Catalog number
2380-25
Name
AT-101 for cell activation
Size
25 mg
Price
507.00 EUR
Supplier
Details
Description
AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.
Peptide sequence
N/A
CAS number
90141-22-3
Molecular weight
518.56
Category
Biochemicals
Other name
(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; (R)-Gossypol
Molecular formula
C₃₀H₃₀O₈
Physical appearance
Light brown solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
