EZCyp™ Active Human Cytochrome P450 2D6
Catalog number
7873-10
Name
EZCyp™ Active Human Cytochrome P450 2D6
Size
10 mg
Price
186.00 EUR
Supplier
Details
Target
EZCyp™ Active Human CYP2D6
Background
Cytochrome P450 2D6 (CYP2D6, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2D6 catalyzes oxidation of lipophilic bases with an aromatic ring and a nitrogen atom and is highly expressed in liver and brain tissue. The enzyme is responsible for metabolism of nearly 25% of all small molecule drugs commonly used by humans, particularly psychiatric drugs such as antidepressants, antipsychotics and stimulants. BioVision’s EZCypTM 2D6 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2D6 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.
Concentration
N/A
Molecular weight
55 Kda
Synonym
Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1
Other name
Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1
NCBI gene number
1565
NCBI gene
CYP2D6
Gene source
Human
NCBI number
P10635
Recombinant
Yes
Source
Pichia pastoris
Purification
N/A
Tested applications
N/A, NA
Level of endotoxin
NA
Tested activity
BioVision K703, Metabolite HPLC
Biological activity
NA
Reesults
NA
Binding ability
NA
Unit
NA
Storage condition
-20°C
Shipping under
gel pack
Physical appearance
Dry powder
Physical properties
Lyophilized powder
How to reconstitute
100 mM Potassium Phosphate buffer, pH 7.7
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
