AKR1C3 Inhibitor II for cell activation

Catalog number
2404-25
Name
AKR1C3 Inhibitor II for cell activation
Size
25 mg
Price
512.00 EUR
Supplier

Details

Description
A highly potent and selective inhibitor of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3 (IC₅₀ = 94 nM). Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC₅₀ >30 µM). Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.
Peptide sequence
No
CAS number
N/A
Molecular weight
322.42
Category
Biochemicals
Other name
1-(4-((2-Methylpiperidin-1-yl)sulfonyl)phenyl)pyrrolidin-2-one
Molecular formula
C₁₆H₂₂N₂O₃S
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.