(-)-Blebbistatin for cell activation

Cell-permeable. The active enantiomer of (±)-Blebbistatin (Cat. No. 2405). A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, (-)-blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.

N/A

856925-71-8

292.34

Biochemicals

1,​2,​3,​3a-​tetrahydro-​3aS-​hydroxy-​6-​methyl-​1-​phenyl-​4H-​Pyrrolo[2,​3-​b]quinolin-​4-​one; (S)-Blebbistatin

C₁₈H₁₆N₂O₂

Yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (~25 mg/ml)

-20 ̊C

gel pack

36 months

Protect from light and air

cell

For cells, cell lines and tissues in culture till half confluency.