24(S)-Hydroxycholesterol for cell activation

An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.  It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma cells, possibly via a necroptosis pathway.  24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM). 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications. It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.

N/A

474-73-7

402.66

Biochemicals

Cerebrosterol, Cholest-5-ene-3,24-diol, (24S)-24-Hydroxycholesterol, cholest-5-en-3beta,24S-diol

C₂₇H₄₆O₂

White solid

N/A

No

Yes

≥99% by HPLC

DMSO (~10 mg/ml) or EtOH (~10 mg/ml)

-20 ̊C

gel pack

36 months

Protect from light and air

cell

For cells, cell lines and tissues in culture till half confluency.