LFM-A13 for cell activation
Catalog number
2414-25
Name
LFM-A13 for cell activation
Size
25 mg
Price
458.00 EUR
Supplier
Details
Description
FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK). It has also been shown to inhibit Polo-like kinase (PLK) (IC₅₀ = 61 µM for human PLK3). It displays no activity (concentrations up to 278 µM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases.
Peptide sequence
N/A
CAS number
244240-24-2
Molecular weight
360
Category
Biochemicals
Other name
(2Z) -2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
Molecular formula
C₁₁H₈Br2N₂O₂
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (~15 mg/ml) or EtOH (~15 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and air
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
