GW 4869 dihydrocloride for cell activation

Catalog number
2417-1
Name
GW 4869 dihydrocloride for cell activation
Size
1 mg
Price
132.00 EUR
Supplier
Biovision
Order

Details

Description
GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF.
Peptide sequence
N/A
CAS number
6823-69-4
Molecular weight
577.5
Category
Biochemicals
Other name
3,​3'-​(1,​4-​phenylene)bis[N-​[4-​(4,​5-​dihydro-​1H-​imidazol-​2-​yl)phenyl]-​2-​propenamide, dihydrochloride; GW69A; GW554869A
Molecular formula
C₃₀H₂₈N₆O₂ · 2HCl [xH₂O]
Physical appearance
Pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥90%
Reconstitute instructions
DMSO (~0.2 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.