Torcetrapib for cell activation
Catalog number
2420-25
Name
Torcetrapib for cell activation
Size
25 mg
Price
577.00 EUR
Supplier
Details
Description
Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed unfavorable off-target effects in cardiovascular system. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.
Peptide sequence
N/A
CAS number
262352-17-0
Molecular weight
600.47
Category
Biochemicals
Other name
(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; CP-529414, CP529414, CP 529414
Molecular formula
C₂₆H₂₅F₉N₂O₄
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (>100 mg/ml) or EtOH (>5 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from light and ai
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
