TPCA-1 for cell activation

A potent and selective inhibitor of IκB kinase-2 (IKK-2) (IC₅₀ = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

N/A

507475-17-4

279.29

Biochemicals

2-[(Aminocarbonyl)amino]-5-(4-fluor​ophenyl)-3-thiophenecarboxamide

C₁₂H₁₀FN₃O₂S

Off-white solid

N/A

No

Yes

≥95% by HPLC

DMSO (~25 mg/ml) or EtOH (~3 mg/ml)

-20 ̊C

gel pack

36 months

Protect from light and air

cell

For cells, cell lines and tissues in culture till half confluency.