Cyclin-dependent kinase inhibitor 2A, Human Recombinant

Catalog number
P1008-100
Name
Cyclin-dependent kinase inhibitor 2A, Human Recombinant
Size
100 μg
Price
1015.00 EUR
Supplier

Details

Synonyms
p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
Alternates names
p16-INK4a, Cyclin-Dependent Kinase Inhibitor 2A, Cyclin-Dependent Kinase 4 Inhibitor A, CDK4I, p16INK4A, p16-INK4, Multiple Tumor Suppressor 1, MTS-1
Taglines
A negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6
Biomolecule/Target
Cyclin-dependent kinase inhibitor 2A
NCBI Gene ID #.
1029
NCBI Gene Symbol
CDKN2A
Gene Source
Human
Accession #
P42771
Recombinant
Yes
Source
E. coli
Purity
≥95%
Endotoxin Level
< 1 EU/μg
Activity (Specifications/test method)
N/A
Biological activity
N/A
Results
N/A
Molecular Weight
16.5 kDa
Storage Temp.
-20°C
Shipping
Gel pack
Shelf Life
1 year
Concentration
N/A
Appearance
Dry powder
Physical form description
Lyophilized powder
Reconstitution Instructions
Reconstitute in sterile PBS (pH 8.0) to a concentration of 0.1-1.0 mg/ml. Do not vortex. Additional carrier protein (example 0.1% BSA) is recommended for long term storage.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Additional source
Recombinants or rec. proteins
Group
recombinants