BAX Activator, BAM7 for cell activation

Catalog number
2451-25
Name
BAX Activator, BAM7 for cell activation
Size
25 mg
Price
458.00 EUR
Supplier

Details

Description
A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.
Peptide sequence
N/A
CAS number
331244-89-4
Molecular weight
405.47
Category
Biochemicals
Other name
3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7
Molecular formula
C₂₁H₁₉N₅O₂S
Physical appearance
Brown solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.