BAX Activator, BAM7 for cell activation

A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.

N/A

331244-89-4

405.47

Biochemicals

3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7

C₂₁H₁₉N₅O₂S

Brown solid

N/A

No

Yes

≥98% by HPLC

-20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.