ETP-46464 for cell activation
Catalog number
2457-5
Name
ETP-46464 for cell activation
Size
5 mg
Price
197.00 EUR
Supplier
Details
Description
A potent ATR (ATM and Rad3-related) inhibitor (IC₅₀ = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC₅₀'s of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart of stalled replication forks and abrogates S phase arrest after exposure to hydroxyurea.
Peptide sequence
N/A
CAS number
1345675-02-6
Molecular weight
470.52
Category
Biochemicals
Other name
2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile; ATRi
Molecular formula
C₃₀H₂₂N₄O₂
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
