Human CellExp™ ICOS / CD278, Human recombinant

Catalog number
9238-10
Name
Human CellExp™ ICOS / CD278, Human recombinant
Size
10 µg
Price
213.00 EUR
Supplier

Details

Target
CD278
Background
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Concentration
N/A
Molecular weight
This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.
Synonym
ICOS, CD278, AILIM
Other name
ICOS, CD278, AILIM
NCBI gene number
29851
NCBI gene
CD278
Gene source
Human
NCBI number
NP_036224
Recombinant
Yes
Source
HEK 293 cells
Purification
N/A
Tested applications
N/A, N/A
Level of endotoxin
< 1 EU/μg
Tested activity
Measured by its binding ability in a functional ELISA.
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.
Reesults
N/A
Binding ability
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized
How to reconstitute
Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants