Human CellExp™ ICOS / CD278, Human recombinant

CD278

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

N/A

This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.

ICOS, CD278, AILIM

ICOS, CD278, AILIM

29851

CD278

Human

NP_036224

Yes

HEK 293 cells

N/A

N/A, N/A

< 1 EU/μg

Measured by its binding ability in a functional ELISA.

Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.

N/A

Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.

N/A

-20°C

Gel pack

Lyophilized

Lyophilized

Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants