Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant
Catalog number
9240-25
Name
Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant
Size
25 µg
Price
550.00 EUR
Supplier
Details
Target
TNFSF9
Background
Tumor necrosis factor ligand superfamily member 9 (4-1BBL) is also known as 4-1BB ligand, CD137L or TNFSF9, which is a cytokine that binds to TNFRSF9. 4-1BBL is the high affinity ligand of 4-1BB. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD). Furthermore, 4-1BBL may play a role in cognate interactions between T-cells and B-cells/macrophages. As for diseases, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Concentration
N/A
Molecular weight
This protein is fused with a Fc tag at C-terminus and has a calculated MW of 47.4 kDa.
Synonym
4-1BB Ligand, TNFSF9, CD137L
Other name
TNFSF9, CD137L
NCBI gene number
8744
NCBI gene
TNFL9
Gene source
Human
NCBI number
P41273
Recombinant
Yes
Source
HEK 293 cells
Purification
>95%
Tested applications
>95%, N/A
Level of endotoxin
< 1 EU/μg
Tested activity
Measured by its binding ability in a functional ELISA.
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 µl/well), can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/ml and immobilized Human 4-1BB Ligand, Fc Tag at 2μ g/ml (100 µl/well), can bind Biotinylated Human 4-1BB, Fc Tag with a linear of 0.5-20 ng/ml.
Reesults
N/A
Binding ability
Measured by its binding ability in a functional ELISA. Immobilized Human 4-1BB, His Tag at 100 ng/mL (100 µl/well), can bind Human 4-1BB Ligand, Fc Tag with a linear of 0.1-2.5 ng/ml and immobilized Human 4-1BB Ligand, Fc Tag at 2μ g/ml (100 µl/well), can bind Biotinylated Human 4-1BB, Fc Tag with a linear of 0.5-20 ng/ml.
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized
How to reconstitute
Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description
FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Additional source
Recombinants or rec. proteins
Group
recombinants
