Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant

TNFRSF4

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

N/A

This protein is fused with a Fc tag at C-terminus and has a calculated MW of 20 kDa.

OX40L,TNFSF4,CD252

OX40L,TNFSF4,CD253

7293

TNFRSF4

Human

NP_003317

Yes

HEK 293 cells

>95%

SDS-PAGE, N/A

< 1 EU/μg

Measured by its binding ability in a functional ELISA.

Immobilized HumanOX40, His Tag at 2 μg/ml (100 μl/well) can bind Human OX40 Ligand, Fc Tag with a linear range of 2-15 ng/ml.

N/A

Immobilized HumanOX40, His Tag at 2 μg/ml (100 μl/well) can bind Human OX40 Ligand, Fc Tag with a linear range of 2-15 ng/ml.

N/A

-20°C

Gel pack

Lyophilized

Lyophilized

Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.

Recombinants or rec. proteins

recombinants