NAALDase Inhibitor, PMPA for cell activation

PMPA is a highly potent and selective inhibitor of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase or glutamate carboxypeptidase II or GCPII) with a Ki value of 275 pM. Displays robust neuroprotective activity in both in vitro and in vivo models of ischemia.

N/A

173039-10-6

226.12

Biochemicals

2-(Phosphonomethyl)pentane-1,5-dioi​c acid; PMPA

C₆H₁₁O₇P

White solid

N/A

N/A

Yes

≥95% by NMR

H₂O (>20 mg/ml)

-20°C

gel pack

24 months

Protect from moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.