Human CellExp™ VSIG4, human recombinant

VSIG4

VSIG4 (V-set and immunoglobulin domain containing 4), as known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation.

N/A

68 kDa

V-set and immunoglobulin domain containing 4; Z39Ig; CRIg

V-set and immunoglobulin domain containing 4; Z39Ig; CRIg

11326

VSIG4

Human

Q9Y279

Yes

HEK 293 cells

≥ 98%

SDS-PAGE, N/A

< 0.06 EU/mg

N/A

N/A

N/A

N/A

N/A

-20°C

Gel pack

Lyophilized

Lyophilized from 0.2μm-filtered solution in PBS.

Reconstitute in 1X PBS to the desired protein concentration.

N/A

Centrifuge the vial prior to opening.

For Research Use Only! Not to be used in humans

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Recombinants or rec. proteins

recombinants