CFTR Inhibitor-172 for cell activation

Catalog number
2487-5
Name
CFTR Inhibitor-172 for cell activation
Size
5 mg
Price
333.00 EUR
Supplier

Details

Description
A potent, reversible, selective, CFTR chloride channel blocker. Inhibits CFTR short-circuit current in < 2 minutes in a voltage-independent manner (Ki = ~ 300 nM). At concentrations fully inhibiting CFTR, CFTR(inh)-172 does not block increase of cellular cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(⁺) channels, or a series of other transporters.
Peptide sequence
N/A
CAS number
307510-92-5
Molecular weight
409.4
Category
Biochemicals
Other name
4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid; CFTR(inh)-172
Molecular formula
C₁₈H₁₀F₃NO₃S₂
Physical appearance
Pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
No
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>10 mg/ml)
Storage condition
- 20°C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.