CFTR Inhibitor-172 for cell activation

A potent, reversible, selective, CFTR chloride channel blocker. Inhibits CFTR short-circuit current in < 2 minutes in a voltage-independent manner (Ki = ~ 300 nM). At concentrations fully inhibiting CFTR, CFTR(inh)-172 does not block increase of cellular cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(⁺) channels, or a series of other transporters.

N/A

307510-92-5

409.4

Biochemicals

4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid; CFTR(inh)-172

C₁₈H₁₀F₃NO₃S₂

Pale yellow solid

N/A

No

No

≥98% by HPLC

DMSO (>10 mg/ml)

- 20°C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.