KN-93 for cell activation

Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.

N/A

139298-40-1

501.04

Biochemicals

N-​[2-​[[[3-​(4-​chlorophenyl)-​2-​propen-​1-​yl]methylamino]methyl]phenyl]-​N-​(2-​hydroxyethyl)-​4-​methoxy-​benzenesulfonamide

C₂₆H₂₉ClN₂O₄S

White solid

N/A

No

Yes

≥98%

DMSO (>40 mg/ml)

-20°C

Gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.