JAK Inhibitor, Pyridone 6 for cell activation

Catalog number
2534-1000
Name
JAK Inhibitor, Pyridone 6 for cell activation
Size
1 mg
Price
273.00 EUR
Supplier

Details

Description
Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.
Peptide sequence
N/A
CAS number
457081-03-7
Molecular weight
309.3
Category
Biochemicals
Other name
2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6
Molecular formula
C₁₈H₁₆FN₃O
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (5 mg/ml)
Storage condition
-20 ̊C
Shipping condition
gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.