JAK Inhibitor, Pyridone 6 for cell activation

Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.

N/A

457081-03-7

309.3

Biochemicals

2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6

C₁₈H₁₆FN₃O

Off-white solid

N/A

No

Yes

≥97% by HPLC

DMSO (5 mg/ml)

-20 ̊C

gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.