EZSolution™ Dorsomorphin for cell activation

Catalog number
2547-5
Name
EZSolution™ Dorsomorphin for cell activation
Size
5 mg
Price
189.00 EUR
Supplier

Details

Description
Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKCθ, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
Peptide sequence
N/A
CAS number
866405-64-3
Molecular weight
399.49
Category
Biochemicals
Other name
6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine; Compound C
Molecular formula
C₂₄H₂₅N₅O
Physical appearance
Liquid
Supplied with
A 10 mM solution in anhydrous DMSO
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
N/A
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.