Human CellExp™ CSF1R/CD115, mouse recombinant, Fc Tag

Catalog number
P1079-10
Name
Human CellExp™ CSF1R/CD115, mouse recombinant, Fc Tag
Size
10 µg
Price
142.00 EUR
Supplier

Details

Target
CSF1R
Background
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Concentration
N/A
Molecular weight
81.8 kDa
Synonym
CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR
Other name
CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CD 115, CD 115 protein, mouse CD 115, recombinant CD 115, mouse recombinant CD 115, mouse CD 115 protein, recombinant CD 115 protein, mouse recombinant CD 115 protein, mouse-r- CD 115, mouse-r- CD 115 protein, CD-115, CD-115 protein, mouse CD-115, recombinant CD-115, mouse recombinant CD-115, mouse CD-115 protein, recombinant CD-115 protein, mouse recombinant CD-115 protein, mouse-r- CD-115, mouse-r- CD-115 protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, CSF1R protein, mouse CSF1R, recombinant CSF1R, mouse recombinant CSF1R, mouse CSF1R protein, recombinant CSF1R protein, mouse recombinant CSF1R protein, mouse-r- CSF1R, mouse-r- CSF1R protein, CSF1R, C-FMS, CD115, CSFR, FIM2, FMS, M-CSFR, September-RP-16
NCBI gene number
12978
NCBI gene
CSF1R
Gene source
Mouse
NCBI number
P09581
Recombinant
Yes
Source
HEK 293 cells
Purification
>95%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
< 1 EU/μg
Tested activity
N/A
Biological activity
N/A
Reesults
N/A
Binding ability
N/A
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
How to reconstitute
Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name
Mus musculus
Additional source
Recombinants or rec. proteins
Group
recombinants