Myriocin (ISP-1) for cell activation
Catalog number
2567-5
Name
Myriocin (ISP-1) for cell activation
Size
5 mg
Price
164.00 EUR
Supplier
Details
Description
A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat. No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.
Peptide sequence
N/A
CAS number
35891-70-4
Molecular weight
401.54
Category
Biochemicals
Other name
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Molecular formula
C₂₁H₃₉NO₆
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (~20 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
