DUB Inhibitor, NSC-632839 for cell activation

Cell-permeable. A pan-specific ubiquitin isopeptidase inhibitor (IC₅₀ = 45, 37 and 9.8 µM for USP2, USP7 and SENP2 respectively). NSC-632839 does not affect proteasome proteolytic activity. Induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.

N/A

157654-67-6

339.86

Biochemicals

3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride

C₂₁H₂₁NO · HCl

Yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (~8 mg/ml)

-20°C

Gel pack

24 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.