RG7388 for cell activation
Catalog number
2577-5
Name
RG7388 for cell activation
Size
5 mg
Price
545.00 EUR
Supplier
Details
Description
RG7388 is highly a potent and selective inhibitor of p53-MDM2 interaction. RG7388 blocks p53−MDM2 binding and effectively activates the p53 pathway, leading to cell cycle arrest and/or apoptosis in cell lines expressing wild-type p53 and tumor growth inhibition or regression of osteosarcoma xenografts in nude mice.
Peptide sequence
N/A
CAS number
1229705-06-9
Molecular weight
616.5
Category
Biochemicals
Other name
4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid
Molecular formula
C₃₁H₂₉Cl₂F₂N₃O₄
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥99% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
24 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
