(±)-Gossypol for cell activation

Isolated from cotton seeds. It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 µM).Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations. Also acts as a non-selective competitive inhibitor of NADH binding to LDH, with K(i) values of 1.9, 1.4, and 4.2 µM for LDH-A4, -B4, and -C4, respectively.

N/A

303-45-7

518.55

Biochemicals

(±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene; NSC 56817; NSC 524336; BL 193; Pogosin

C₃₀H₃₀O₈

Yellow solid

N/A

No

Yes

≥95%

DMSO (>10 mg/ml) or EtOH (>10 mg/ml with slight warming)

-20°C

Gel pack

24 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.