Human CellExp™ ICOSLG /B7-H2 /CD275, mouse recombinant
Catalog number
P1106-10
Name
Human CellExp™ ICOSLG /B7-H2 /CD275, mouse recombinant
Size
10 μg
Price
142.00 EUR
Supplier
Details
Target
Icoslg
Background
Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Concentration
N/A
Synonym
B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
Other name
B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
NCBI gene number
50723
NCBI gene
Icoslg
Gene source
Mouse
NCBI number
Q9JHJ8
Recombinant
Yes
Source
CHO cells
Purification
≥95%
Tested applications
SDS-PAGE, N/A
Level of endotoxin
< 0.06 EU/μg
Tested activity
Measured by its binding ability in a functional ELISA.
Biological activity
Immobilized human ICOS at 1μg/ml (100μl/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0μg/ml.
Reesults
N/A
Binding ability
Immobilized human ICOS at 1μg/ml (100μl/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0μg/ml.
Unit
N/A
Storage condition
-20°C
Shipping under
Gel pack
Physical appearance
Lyophilized
Physical properties
Lyophilized from 0.2 μm-filtered solution in PBS
How to reconstitute
Reconstitute at 100 μg/ml in sterile PBS
Aa sequence
N/A
Before use
Centrifuge the vial prior to opening.
Notes
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name
Mus musculus
Additional source
Recombinants or rec. proteins
Group
recombinants
