BTK Inhibitor, CNX-774 for cell activation

CNX-774 is a potent, irreversible BTK inhibitor (IC₅₀ < 1 nM). CNX-774 is highly selective for BTK, and forms a ligand-directed covalent bond with the Cys-481 residue within the ATP binding site of the enzyme.

N/A

1202759-32-7

499.5

Biochemicals

4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide

C₂₆H₂₂FN₇O₃

Crystalline solid

N/A

No

Yes

>98% by HPLC

DMSO

-20 ̊C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.