FLI-06 for cell activation

A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.

N/A

313967-18-9

438.52

Biochemicals

Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

C₂₅H₃₀N₂O₅

Yellow solid

N/A

No

Yes

>98% by HPLC

DMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)

-20 ̊C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.