UNC0646 for cell activation

UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.

N/A

1320288-17-2

621.9

Biochemicals

N-​(1-​cyclohexyl-​4-​piperidinyl)-​2-​[hexahydro-​4-​(1-​methylethyl)-​1H-​1,​4-​diazepin-​1-​yl]-​6-​methoxy-​7-​[3-​(1-​piperidinyl)propoxy]-​4-​quinazolinamine

C₃₆H₅₉N₇O₂

Pale yellow solid

N/A

No

Yes

>98% by HPLC

DMSO (~50 mg/ml) or EtOH (~50 mg/ml)

-20 ̊C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.