JW55 for cell activation

JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the β-catenin destruction complex, followed by increased degradation of β-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of β-catenin.

N/A

664993-53-7

434.48

Biochemicals

N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

C₂₅H₂₆N₂O₅

Off-white solid

N/A

No

Yes

>98% by HPLC

DMSO(~ 40 mg/ml) or EtOH (~ 40 mg/ml)

-20 ̊C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.