CAL-101 (GS-1101) for cell activation
Catalog number
2613-5
Name
CAL-101 (GS-1101) for cell activation
Size
5 mg
Price
132.00 EUR
Supplier
Details
Description
CAL-101 is a cell-permeable inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 2.5 nM) that displays 40- to 300-fold selectivity against other PI3K class I enzymes (IC₅₀s = 820, 565, and 89 nM for p110α, β, and γ, respectively). It has also been shown to inhibit the chemotaxis of chronic lymphocytic leukemia cells and to downregulate the secretion of chemokines triggered by B-cell receptor signaling.
Peptide sequence
N/A
CAS number
870281-82-6
Molecular weight
415.42
Category
Biochemicals
Other name
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone; Idealisib
Molecular formula
C₂₂H₁₈FN₇O
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98% by HPLC
Reconstitute instructions
DMSO(~ 25 mg/ml) or EtOH (~ 15 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
