Leucettine L41 for cell activation
Catalog number
2617-1
Name
Leucettine L41 for cell activation
Size
1 mg
Price
142.00 EUR
Supplier
Details
Description
A potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3α/β, CK2 and PIM1. Interacts with the complex IKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Useful to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death.
Peptide sequence
N/A
CAS number
1112978-84-3
Molecular weight
307.3
Category
Biochemicals
Other name
(5Z)-5-(1,3-Benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4H-imidazol-4one
Molecular formula
C₁₇H₁₃N₃O₃
Physical appearance
Beige solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98% by NMR
Reconstitute instructions
DMSO or EtOH
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
