NVP-BKM120 for cell activation
Catalog number
2619-25
Name
NVP-BKM120 for cell activation
Size
25 mg
Price
414.00 EUR
Supplier
Details
Description
NVP-BKM120 is a potent inhibitor of class I PI3K isoforms; potently blocks both p110α (IC₅₀ = 52 nM) and p110β (IC₅₀ = 166 nM) in vitro. It is much less effective against the class III PI3K Vps34 and mammalian target of rapamycin (mTOR) and has no effect on PI4Kβ and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 μM and inhibits tumor growth in vivo.
Peptide sequence
N/A
CAS number
944396-07-0
Molecular weight
410.39
Category
Biochemicals
Other name
(5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; BKM-120; Buparlisib
Molecular formula
C₁₈H₂₁F₃N₆O₂
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>95% by HPLC
Reconstitute instructions
DMSO (~15 mg/ml) or EtOH (~15 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
