Stattic for cell activation
Catalog number
2625-25
Name
Stattic for cell activation
Size
25 mg
Price
371.00 EUR
Supplier
Details
Description
Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC₅₀ = 5.1 μM at 37°C). Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.
Peptide sequence
N/A
CAS number
19983-44-9
Molecular weight
211.19
Category
Biochemicals
Other name
6-Nitro-1,1-dioxide-benzo[b]thiophene; Stat3 Inhibitor V
Molecular formula
C₈H₅NO₄S
Physical appearance
Pale yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>98%
Reconstitute instructions
DMSO (~ 25 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
