AM580 for cell activation

AM580 is an analog of Retinoic acid (Cat. No. 2218) that acts as aretinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (Kd = 131 nM; AC₅₀ = 24.6 nM) and RARγ (Kd = 450 nM; AC₅₀ = 27.9 nM). It displays greater specific binding to RARα compared to retinoic acid which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Cat. No.1677) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.

N/A

102121-60-8

351.44

Biochemicals

4-​​[[(5,​​6,​​7,​​8-​​tetrahydro-​​5,​​5,​​8,​​8-​​tetramethyl-​​2-​​naphthalenyl)​carbonyl]​amino]​-​benzoic acid; RO 40-6055; CD336; NSC 608001

C₂₂H₂₅NO₃

White solid

N/A

No

Yes

>98%

DMSO (~ 15 mg/ml)

-20 ̊C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.