CD437 for cell activation

Catalog number
2636-5
Name
CD437 for cell activation
Size
5 mg
Price
197.00 EUR
Supplier

Details

Description
CD437 is the adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kds = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively). CD437 is cytotoxic to the acute myeloid leukemia cell line NB4 (EC₅₀ = 0.17 μM), inducing DNA damage by producing DNA double strand breaks. CD437 also induces cell cycle arrest and apoptosis in various other cancer cells including melanoma, breast, non-small lung, and prostate cancer cells through RAR-dependent and -independent signaling pathways. Treatment of mouse embryonic fibroblasts (MEFs) with CD437 early in the reprogramming process significantly increases reprogramming efficiency up to 20-fold.
Peptide sequence
N/A
CAS number
125316-60-1
Molecular weight
398.49
Category
Biochemicals
Other name
6-​(4-​hydroxy-​3-​tricyclo[3.3.1.13,​7]dec-​1-​ylphenyl)-​2-​naphthalenecarboxylic acid; AHPN
Molecular formula
C₂₇H₂₆O₃
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
>95%
Reconstitute instructions
DMSO (>10 mg/ml)
Storage condition
-20 ̊C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.