LGK974 for cell activation
Catalog number
2645-5
Name
LGK974 for cell activation
Size
5 mg
Price
414.00 EUR
Supplier
Details
Description
LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.
Peptide sequence
N/A
CAS number
1243244-14-5
Molecular weight
396.44
Category
Biochemicals
Other name
2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
Molecular formula
C₂₃H₂₀N₆O
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 35 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
