LY-411575 for cell activation
Catalog number
2648-1
Name
LY-411575 for cell activation
Size
1 mg
Price
142.00 EUR
Supplier
Details
Description
LY411575 is a potent, cell-permeable γ-secretase inhibitor (IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based); also inhibits Notch clevage with with IC₅₀ of 0.39 nM. Notch inhibition using LY-411575 induces cochlear hair cell regeneration and recovery of hearing in mice after acoustic trauma.
Peptide sequence
N/A
CAS number
209984-57-6
Molecular weight
479.48
Category
Biochemicals
Other name
N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide; LSN-411575
Molecular formula
C₂₆H₂₃F₂N₃O₄
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
48 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
